Development of Controlled Environments for Printing Microfabrication Process of Low-cost Biochips for multiple and parallel blood analyses

血液测试是临床诊断中最常用的方法，因为血液分析提供了患者医疗状况的确切信息。迫切需要开发用于血液分析的低成本和易于使用的护理点生物芯片。基于CD的生物芯片成为实现这一目标的最有前途的方法之一。申请人和他的团队一直致力于开发用于多重和平行血液分析的基于CD的生物芯片。这种努力包括他们最近发明的平面外阀（Yang等人，J. Micromech。微英。2010年），这使得芯片上的血液分离和计量非常简单。由于其结构简单和易于控制的机制，基于平面外阀创新的新型CD基生物芯片设计可以实现高性能的血液分析，同时将制造成本降低到现有商业产品的10%。

Blood testing is the most commonly-used method in clinical diagnosis because blood analyses provide definitive information of patients' medical conditions. There is urgent need for developing low-cost and easy-to-use point-of-care biochips for blood analyses. CD-based biochips emerge as one of the most promising approaches to achieve this goal. The applicant and his team have constantly dedicated themselves to developing CD-based biochips for multiple and parallel blood analyses. Such effort includes their recent invention of the out-of-plane valve (Yang et al., J. Micromech. Microeng. 2010) that makes on-chip blood separation and metering extremely simple. Because of its structural simplicity and easy-to-control mechanism, a novel CD-based biochip design based on the out-of-plane valve innovation can achieve high performance blood analyses, and meanwhile reduce the manufacturing cost down to 10% of existing commercial products.