A micro/nanotechnology based approach enabling definite and quantitative studies of biotransport phenomena in microvascular networks

基于微/纳米技术的方法能够对微血管网络中的生物转运现象进行明确和定量的研究

• 批准号: 327642-2011
• 负责人: Yang, Jun
• 金额: $ 2.33万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=572084
• 关键词: micro; nanotechnology; based; approach; enabling

Micro/nanotechnology, as an enabling tool, has significantly extended our capability to control local microenvironment with high temporal and spatial resolution, and to conduct quantitative measurements with high biochemical selectivity and sensitivity. There are unprecedented opportunities for research when we apply state-of-the-art micro/nanotechnology to solve the scale challenges that often occur in traditional biomedical studies. In this application, we will develop a novel micro/nanotechnology-enabled approach that will largely facilitate biotransport research at the microcirculation level. Exchanging gases, nutrients and waste products between tissue and blood, microcirculation play a central role in living systems. On the other hand, microvascular dysfunction causes tissue hypoxia and organ failure in sepsis and interplays with diseases such as hypertension, obesity and diabetes. The proposed research will enable quantitative measurements on microvascular response and blood flow regulation through well-controlled and localized chemical delivery. Such detailed biotransport information will significantly advance our understanding of physiology in microcirculation. Additionally the biotechnology to be developed and knowledge that we will learn in this project will further be applied to clinical diagnostics, drug discovery and therapeutics of cardiovascular disease. Eventually the proposed research will benefit health care in Canada.

微/纳米技术，作为一种使能工具，显着扩展了我们的能力，以高时空分辨率控制局部微环境，并进行定量测量与高生化选择性和灵敏度。当我们应用最先进的微/纳米技术来解决传统生物医学研究中经常出现的规模挑战时，研究有前所未有的机会。 在这个应用中，我们将开发一种新的微/纳米技术使能的方法，这将在很大程度上促进微循环水平的生物运输研究。微循环在组织和血液之间交换气体，营养物质和废物，在生命系统中发挥着核心作用。另一方面，微血管功能障碍导致脓毒症中的组织缺氧和器官衰竭，并与高血压、肥胖和糖尿病等疾病相互作用。拟议的研究将通过良好控制和局部化的化学物质输送来定量测量微血管反应和血流调节。这些详细的生物转运信息将大大促进我们对微循环生理学的理解。此外，我们将在本项目中开发的生物技术和学习的知识将进一步应用于心血管疾病的临床诊断，药物发现和治疗。最终，拟议的研究将有利于加拿大的医疗保健。