A micro/nanotechnology based approach enabling definite and quantitative studies of biotransport phenomena in microvascular networks

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Micro/nanotechnology, as an enabling tool, has significantly extended our capability to control local microenvironment with high temporal and spatial resolution, and to conduct quantitative measurements with high biochemical selectivity and sensitivity. There are unprecedented opportunities for research when we apply state-of-the-art micro/nanotechnology to solve the scale challenges that often occur in traditional biomedical studies. In this application, we will develop a novel micro/nanotechnology-enabled approach that will largely facilitate biotransport research at the microcirculation level. Exchanging gases, nutrients and waste products between tissue and blood, microcirculation play a central role in living systems. On the other hand, microvascular dysfunction causes tissue hypoxia and organ failure in sepsis and interplays with diseases such as hypertension, obesity and diabetes. The proposed research will enable quantitative measurements on microvascular response and blood flow regulation through well-controlled and localized chemical delivery. Such detailed biotransport information will significantly advance our understanding of physiology in microcirculation. Additionally the biotechnology to be developed and knowledge that we will learn in this project will further be applied to clinical diagnostics, drug discovery and therapeutics of cardiovascular disease. Eventually the proposed research will benefit health care in Canada.