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Nature and morphogenesis of the intracellular compartments established by commensal and pathogenic bacteria in dendritic cells

Nature and morphogenesis of the intracellular compartments established by commensal and pathogenic bacteria in dendritic cells
树突状细胞中共生菌和病原菌建立的细胞内区室的性质和形态发生
批准号:
355655-2008
负责人:
Terebiznik, Mauricio
金额:
$2.55万
依托单位:
依托单位国家:
加拿大
项目类别:
Discovery Grants Program - Individual
财政年份:
2012
资助国家:
加拿大
项目状态:
已结题
起止时间:
2012-01-01 至 2013-12-31

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中文摘要
翻译
树突状细胞(DC)是免疫系统的关键组成部分。这些细胞将肠道上皮细胞的样本吞入细胞内的病原菌区室称为吞噬体。在吞噬体内,细菌被杀死并被消化。独特的细菌成分,如蛋白质片段,然后由DC呈递给淋巴细胞。这个动作激活淋巴细胞,这将打击细菌感染。
英文摘要
Dendritic cells (DCs) are a key component of the immune system. These cells sample the gut epithelium engulfing pathogenic bacteria into intracellular compartments known as phagosomes. Inside phagosomes bacteria are killed and digested. Distinctive bacterial components, like protein fragments, are then presented by DCs to the lymphocytes. This action activates lymphocytes, which will fight the bacterial infection.
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