The role of RanGTP in the spatial organization of mitotic cells

为了让生物体生长和发展，它们必须不断增加体内的细胞数量。为了实现这一点，细胞可以一分为二。为了让两个合成的细胞存活下来，它们必须拥有生物体遗传物质的完整补充，否则它们将死亡或变得不受调控。因此，只有当遗传物质复制和分离时，细胞分裂才会发生，否则遗传物质在两个新形成的细胞之间会有不均匀的分配。我们有证据表明，每个细胞中的染色体有助于在空间上组织一个细胞，这样它就只会分裂，产生两个基因含量相等的细胞。我们打算确定染色体是如何调节细胞分裂过程的。

For organisms to grow and develop they must continually increase the numbers of cells within them. To achieve this cells can divide into two. For the two resultant cells to survive they must have a complete complement of the organisms genetic material, otherwise they will die or become misregulated. Therefore cell division must only occur once the genetic material has duplicated and separated, otherwise there would be an unequal distribution of the genetic material between the 2 newly forming cells. We have evidence to suggest that the chromosomes in each cells contribute to spatially organizing a cell so that it will only divide to produce two cells with an equal genetic content. We porpose to determine how the chromosomes regulate the process of cell division.