NSERC CREATE Training Program in Cellular dynamics of macromolelecular complexes

传统的科学培训方案主要立足于个别学科和学术部门，没有为学生提供当今劳动力市场所需的适当的跨学科和以实践为导向的培训。这里提出的“大分子复合体细胞动力学”(CDMC)培训计划将有助于弥合分子生物科学最重要领域的这一关键差距。该方案将有一个重要的职业发展部分，并为学生提供专业技能培训以及科学发现商业化、知识产权保护和私营部门和政府研究实践方面的培训。该计划的科学内容回应了对许多生物基因组信息的破译，这导致了关于细胞分子成分及其已知或预测的相互作用的信息溢出。这些分子相互作用的总和被定义为细胞的“相互作用体”。许多相互作用同时发生，为了生存，细胞进化出调节大分子伙伴(蛋白质、DNA和RNA)之间的分子相互作用的机制。要了解这些相互作用的分子基础和动力学，需要破译哪些相互作用对细胞功能重要，并对这些信息进行量化。这些问题的复杂性构成了一个重大挑战，来自不同科学学科(生物学、化学、信息学)的方法和真正的跨学科培训对于推动该领域的研究是必要的。这是促进科学知识及其在生物技术部门和制药业中的商业应用的先决条件。

Classical scientific training programs are primarily anchored in individual disciplines and academic departments and do not provide students with the appropriate interdisciplinary and praxis-oriented training required for the labour market of today. The "Cellular Dynamics of Macromolecular Complexes" (CDMC) training program proposed here will help to close this critical gap in a most important area of the molecular biosciences. This program will have a substantial professional development component and provide students with professional skills training as well as training in the commercialization of scientific discoveries, the protection of intellectual property and the practice of research in the private sector and in government. The scientific content of this program responds to the deciphering of genomic information of many organisms that has resulted in an overflow of information on cellular molecular components and their known or predicted interactions. The sum of these molecular interactions has been defined as the "interactome" of cells. Many interactions occur at the same time and in order to survive, cells have evolved mechanisms to regulate the molecular interactions between macromolecular partners (proteins, DNA and RNA). Understanding the molecular basis and the dynamics of these interactions requires deciphering which interactions are important to cellular function and to quantify this information. The complexity of these questions constitutes a major challenge and approaches from distinct scientific disciplines (Biology, Chemistry, Informatics) and truly inter-disciplinary training are necessary to advance research in the field. This is a prerequisite for the advancement of scientific knowledge as well as for its commercial applications in the biotech sector and in the pharmaceutical industry.