Zebrafish housing unit and biosafety cabinet

斑马鱼是研究发育和生理过程以及研究人类疾病相关事件的优秀模式生物。我们一直在用斑马鱼来探索激素和生长因子如何调节生殖，特别是卵子的发育和成熟。我们希望以斑马鱼为模型，研究卵巢癌细胞如何侵入其他组织和器官，并检验基因在血管形成中的功能。在本提案中，要求拨款购买一个独立的斑马鱼住房机架系统和一个生物安全柜。住宅系统配备过滤器和紫外线消毒器，以及控制和监测系统，以确保最佳的水质。这为斑马鱼提供了一个健康舒适的环境。在进行实验过程中，需要一个生物安全柜来保护研究人员免受潜在的生物危害剂的影响，并使细胞和组织培养物免受潜在的污染。这些仪器将使我们能够进行创新研究，这不仅将增强我们对生殖功能如何控制的理解，而且还具有潜在的临床应用。

Zebrafish is an excellent model organism to study developmental and physiological processes and to investigate events related to human diseases. We have been using zebrafish to explore how hormones and growth factors regulate reproduction, particularly egg development and maturation. We would like to use zebrafish as a model to study how ovarian cancer cells invade other tissues and organs and to examine the functions of genes in blood vessel formation. In this proposal, funding is requested to purchase a stand-alone zebrafish housing rack system and a biosafety cabinet. The housing system is equipped with filters and ultra-violet sterilizers, as well as control and monitoring system to ensure optimal water quality. This provides a healthy and comfortable environment for zebrafish. A biosafety cabinet is required to protect researchers from potential biohazardous agents when perform experimental procedure and to keep the cell and tissue cultures free from potential contaminations. These instruments will allow us to conduct innovative research that will not only enhance our understanding on how reproductive functions are controlled, but also have potential clinical applications.