Pharmacological and Optogenetic approaches to study neural control of breathing

节律性呼吸活动在脑干中由分布于下髓质的神经元网络产生，并受到化学敏感驱动和脑状态活动的高度影响。我们的实验室对呼吸节奏在体内是如何产生和调节的感兴趣，特别是关于两个被提出的脑干区域在不同发育阶段、不同大脑状态水平和不同神经调节输入期间分别驱动吸气和呼气节律活动的功能作用。

Rhythmic respiratory activity is generated in the brainstem by a network of neurons distributed in the lower medulla and is highly influenced by chemosensitive drive and brain state activity. Our laboratory is interested in how respiratory rhythms are generated and modulated in vivo, especially regarding the functional role of the two proposed brainstem regions that drive inspiratory and expiratory rhythmic activity, respectively, across different stages of development, in different brain state levels and during different neuromodulatory inputs.