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Mechanisms of Aspergillus induced chronic airway disease

Mechanisms of Aspergillus induced chronic airway disease
曲霉菌诱发慢性气道疾病的机制
批准号：
252045
负责人：
Sheppard Donald C
金额：
$39.01万
依托单位：
McGill University
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2012
资助国家：
加拿大
项目状态：
已结题
起止时间：
2012-03-01 至 2017-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=252045&lang=en
关键词：
Aspergillus Fumigatus Chronic Lung Disease Cystic Fibrosis Inflammation Mast Cells

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中文摘要
翻译
多达一半的囊性纤维化患者的肺部都有烟曲霉，导致肺功能恶化。抗真菌治疗很少能成功根除真菌，这表明需要新的治疗方法来治疗这种疾病。
英文摘要
The mold Aspergillus fumigatus colonizes the lungs of up to half of patients with cystic fibrosis, whose lung function then worsens. Antifungal therapy is rarely successful in eradicating the fungus, suggesting a need for new therapies for this condition.
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会议论文
Development of immunotherapeutics against Aspergillus fumigatus
Identification and characterization of a novel polysaccharide virulence factor of Aspergillus fumigatus
Human Fungal Infections - Targeting host-pathogen interactions to develop novel antifungal therapies
Recombinant hydrolases as anti-biofilm therapies for Aspergillus infections
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