Radiation detectors for large area biomedical imaging

拟议研究的总体目标是推进大面积有源矩阵平板探测器（FPD）技术，以实现新兴的低光子通量、实时、大面积生物医学成像应用，如3D筛查乳腺X射线断层摄影、蛋白质晶体学、X射线衍射和散射成像。 这将通过从电路、器件和工艺水平改进辐射探测器，同时使用行业标准制造工艺来实现。使用所提出的方法的主要好处是充分利用了成熟的有源矩阵液晶显示器（AMLCD）制造基础设施和成熟的硅电路设计技术在过去三十年中开发的能力。 在这项研究中，我们解决了FPD技术广泛采用的关键瓶颈：动态范围，空间分辨率和成本。

The overall objective of the proposed research is to advance large area active matrix flat panel detector (FPD) technology to enable emerging low photon fluence, real-time, large area, biomedical imaging applications such as 3D screening mammography tomosynthesis , protein crystallography, X-ray diffraction and scatter imaging. This will be accomplished by improving upon radiation detectors from a circuit, device and process level while using industry standard fabrication processes. The primary benefits of using the proposed approach is to leverage the capabilities of the well-established active matrix liquid crystal display (AMLCD) fabrication infrastructure and the mature silicon circuit design techniques developed over the past three decades. In this research, we address the key bottlenecks to the widespread adoption of FPD technology: dynamic range, spatial resolution and cost.