Nano/Microscale Medical Devices

我们的研究计划是我们之前工作的继续，目的是开发用于纳米医学和再生医学的纳米/微设备。因此，近年来，我们开发了用于基因控制释放的壳聚糖纳米颗粒和用于神经再生的碳纳米管复合材料。最近，我们合作开发了一种磁驱动纳米机器人来系统地输送药物，并通过磁驱动纳米矢量器通过肺部输送一氧化氮。我们已经建立了纳米尺度的表面分析技术，以及适合纳米材料的生物相容性和血液相容性的评估方法。正在进行的物理化学性质和生物反应之间的相关性研究工作应该可以更好地理解蛋白质吸附在被称为“日冕”的纳米颗粒上的现象。我们在未来几年的目标如下：1)表征三种在纳米医学方面具有巨大潜力的超顺磁性纳米颗粒(Fe3O4、磁小体、Fe7C3)的物理化学性质和磁性(高温)；2)研究这些SPMNPs与蛋白质的相互作用机制和纳米毒性机制(活性氧物种、离子溶解等)。为了阐明其生物相容性和血液相容性，3)开发纳米/微型医疗器械：(I)用于附着和控制释放一氧化氮的SPMNPs的功能化，用于抗菌和抗癌治疗；(Ii)SPMNPs的功能化，用于控制释放止痛肽；(Iii)SPMNPs的官能化，用于捕获和去除血液中的低密度脂蛋白(LDL)；4)研究静磁场和射频电磁场暴露对SPMNPs毒性的影响，因为这些纳米/微设备是由磁共振成像(MRI)驱动的。

Our research program is the continuation of our previous work aiming to develop nano/micro devices for nanomedicine and regenerative medicine. Thus, in recent years, we have developed chitosan nanoparticles for controlled release of genes and composites based on carbon nanotubes for nerve regeneration. Recently, we collaborated to develop a magnetically driven nanorobot to deliver drugs systemically and magnetically driven nanovector for delivering nitric oxide via the lungs. We have established techniques for surface analysis at the nanoscale as well as methods for the evaluation of biocompatibility and hemocompatibility suited for nanomaterials. Ongoing work on the studies of correlation between physiochemical properties and biological response should provide a better understanding of the phenomenon of protein adsorption to nanoparticles called the "corona". Our objectives for the coming years are as follows: 1) Characterization of physicochemical properties and magnetic properties (hyperthermia) of three superparamagnetic nanoparticles (SPMNPs) (Fe3O4, magnetosomes, Fe7C3) with great potential in nanomedicine; 2) Study of the mechanisms of interaction of these SPMNPs with proteins and nanotoxicity mechanisms (reactive oxygen species, ionic dissolution, ...) in order to elucidate their biocompatibility and hemocompatibility; 3) Development of nano/micro medical devices: (i) functionalization of SPMNPs for attachment and controlled release of nitric oxide for antibacterial and anticancer treatments; (ii) Functionalization of SPMNPs for controlled release of anti-pain peptides; (iii) Functionalization of SPMNPs to capture and remove low-density lipoproteins (LDLs) from blood; 4) Study of the effects of exposure to both static magnetic and radiofrequency electromagnetic fields on the toxicity of SPMNPs, since these nano/micro devices are driven by magnetic resonance imaging (MRI).