Control mechanisms in pulsatile blood flow: an engineering view

多年来，血液流动一直被严格视为一个独立的流体动力(管道)系统，仅受压力和流动的物理规律的制约。事实上，除了这些规律外，血液流动一直受到自主神经系统的控制和调节。造成这种情况的原因是，血液流动的研究传统上一直在工程学和数学领域，而自主神经系统的研究一直严格地在生理学领域。在过去的大约40年里，我在第一个领域工作，与另一个领域的研究人员进行了大量的合作工作，我相信我现在已经建立了足够的合作链接，使我能够将这两个系统结合在一起。这项提案代表了一项这样做的研究计划。

For many years blood flow has been considered strictly as a stand-alone fluid dynamic (plumbing) system, subject to only the physical laws of pressure and flow. In reality, in addition to these laws, blood flow is at all times subject to control and regulation by the autonomic nervous system. The reason for this situation is that the study of blood flow has traditionally been in the domain of engineering and mathematics while the study of the autonomic nervous system has been strictly in the domain of physiology. Having worked in the first of these domains in the last 4 decades or so, with considerable collaborative work with researches in the other domain, I believe I have now established sufficient collaborative links to enable me to put these two systems together. This proposal represents a research program for doing so.