Statistical methodology in the health sciences

我的研究的主要目的是发展和评估统计方法，可以有效地应用于健康科学研究。这种研究的大部分涉及在标准统计技术由于违反基本假设而不适当时可能应用的方法的发展。这方面的一个例子是我过去和正在进行的关于集群随机试验分析方法的研究，这种试验分配完整的社会单位而不是个体进行治疗。由于群集中的个体不能被视为在统计上独立，标准的分析方法不适用，并可能导致误导性的结论。我在这个领域的大部分研究都集中在开发一种方法上，这种方法考虑了集群内的依赖关系，从而使所得到的推论具有有效和高效的统计特性。我的教科书《聚类随机化试验的设计与分析》（与尼尔·克拉尔合著）（阿诺德出版公司，2000年）对这一主题进行了全面的论述。本文的中文译本于2006年出版。

The principal objective of my research is to develop and evaluate statistical methodology that may be usefully applied to health sciences research. Most of this research involves the development of methods that may be applied when standard statistical techniques are inappropriate, due to the violation of underlying assumptions. An example of this is my past and continuing research on methods of analysis for cluster randomization trials which allocate intact social units rather than individuals to treatment. Since individuals within a cluster cannot be regarded as statistically independent, standard methods of analysis do not apply, and could result in misleading conclusions. Much of my research in this area has been focused on the development of methods that take into account within-cluster dependencies in such a way that the resulting inferences have valid and efficient statistical properties. My textbook "Design and Analysis of Cluster Randomization Trials", co-authored with Neil Klar (Arnold Publishing Co., 2000) presents a comprehensive treatment of this subject.The Chinese translated edition of this text was published in 2006.