Statistical methods to characterize causal mechanisms by which air pollution affects the recurrence of cardiovascular events
描述空气污染影响心血管事件复发因果机制的统计方法
基本信息
- 批准号:10660281
- 负责人:
- 金额:$ 179.01万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-23 至 2026-08-31
- 项目状态:未结题
- 来源:
- 关键词:Acute myocardial infarctionAddressAdoptionAffectAgeAir PollutantsAir PollutionAttentionBehaviorBiologicalCardiovascular DiseasesCardiovascular systemCause of DeathCessation of lifeClinicalClinical PathwaysCollectionComputer softwareDataData CollectionData SourcesDiseaseDisease ProgressionEnrollmentEnsureEnvironmental HealthEpidemiologyEventExposure toFee-for-Service PlansGenderGoalsHealthHealth HazardsHeart DiseasesHospitalizationHyperlipidemiaHypertensionIndividualInpatientsKnowledgeLinkMediatingMediationMediatorMedicareMedicare Part AMedicare claimMethodologyMethodsModelingModernizationNatureNitrogen DioxideOutcomeOutpatientsOzoneParameter EstimationPathway interactionsPeer ReviewPoliciesProceduresProcessRaceRecurrenceRiskSamplingScourgeStatistical MethodsStructural ModelsSurveysSyndromeTechniquesTimeVisitWorkambient air pollutionbeneficiaryburden of illnesscardiovascular disorder riskcomputational platformfine particleshuman old age (65+)improvedinnovationmortalitynovelopen sourcepollutantpreventprimary outcomesecondary analysissemiparametricsimulationstatistical and machine learning
项目摘要
Project Summary
One of our era's greatest scourges is air pollution, and it is well documented that exposure to fine particles (e.g.,
PM2.5) increases the risk of cardiovascular disease (CVD) and death. However, there are two critical knowledge
gaps. First, existing studies have mainly considered the occurrence of the first adverse health event as health out-
comes; hence, the impact of overall disease burden and of PM2.5 exposure on disease progression both remain
unknown. Second, to our knowledge, there are no studies assessing the causal pathways by which exposure
to air pollutants impacts recurrent cardiovascular events. Without a better understanding of disease progression
and clinical mediators, our ability to inform regulatory policy and prevent disease is severely hampered.
Limited attention has been given to developing methods for assessing the causal effect of time varying ex-
posures, especially in the presence of a terminating event like death. A related methodological gap is the ability
to identify (time varying) mediators or estimating mediated effects of time varying exposure for a recurrent event
outcome. This proposal addresses these two critical methodological gaps in causal inference, the overarching
goals being to elucidate (i) the impact of PM2.5 on the burden and progression of CVD; and, (ii) the key causal
pathways by which air pollution exposure impacts such events. Accomplishing such goals will be facilitated by
new analyses of an unprecedented data collection consisting of (a) an already harmonized and linked Part A
Medicare data (33+ million subjects 2000 to 2019) at both the individual (e.g., age, gender, race, date of hospital-
ization for any of the possible causes for hospitalizations, date of death) and zip code (e.g., daily PM2.5, O3 and
NO2 levels; many potential confounders) levels; and, (b) an augmented version of these data including individu-
ally linked Part B data (doctor visits, and outpatient procedures for any cause) for a representative sample of over
15 million Medicare enrollees (2012 to 2019) and, (c) the Medicare Current Beneficiary Survey (MCBS) data for
the same study period, as a secondary analysis to account for possible bias due to unmeasured confounding.
In methodological terms, we propose robust marginal and structural nested models that allow estimation of
both instantaneous and delayed effects of time varying exposure to PM2.5 on recurrence of CVD events (Aim 1).
We further propose a semiparametric approach to identify clinically important pathways by which exposure to air
pollutants increases the risk of recurrence of CVD hospitalizations and death, and estimate the corresponding
mediated effects (Aim 2). We will implement our methods and apply them to the above-described rich data
source, focusing specifically on (Aim 3): (i) estimating the causal effects of PM2.5 exposure on two relevant
causal estimands for recurrent events in the presence of mortality; (ii) identifying key mediators and characterize
clinical pathways through which exposure to air pollution increases risks of CVD progression and death; and,
(iii) identifying and investigating the disease groups that are biologically plausible. Finally, we will create and
disseminate open-source, peer-reviewed statistical software to ensure ease-of-use and accessibility (Aim 4).
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Francesca Dominici其他文献
Francesca Dominici的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Francesca Dominici', 18)}}的其他基金
CAFÉ: a Research Coordinating Center to Convene, Accelerate, Foster, and Expand the Climate Change and Health Community of Practice
CAF:一个研究协调中心,旨在召集、加速、培育和扩大气候变化与健康实践社区
- 批准号:
10689581 - 财政年份:2023
- 资助金额:
$ 179.01万 - 项目类别:
Augmented mapping of the Extreme Heat and Cold Events (EHE/ECE) at continental scale with cloud-based computing
利用基于云的计算对大陆范围内的极热和极冷事件 (EHE/ECE) 进行增强测绘
- 批准号:
10826885 - 财政年份:2022
- 资助金额:
$ 179.01万 - 项目类别:
The confluence of extreme heat cold on the health and longevity of an Aging Population with Alzheimers and related Dementia
极热寒冷对患有阿尔茨海默病和相关痴呆症的老年人口的健康和寿命的影响
- 批准号:
10448053 - 财政年份:2022
- 资助金额:
$ 179.01万 - 项目类别:
Relationship Between Multiple Environmental Exposures and CVD Incidence and Survival: Vulnerability and Susceptibility
多重环境暴露与 CVD 发病率和生存率之间的关系:脆弱性和易感性
- 批准号:
10163485 - 财政年份:2020
- 资助金额:
$ 179.01万 - 项目类别:
Integrating Air Pollution Prediction Models: Uncertainty Quantification and Propagation in Health Studies
整合空气污染预测模型:健康研究中的不确定性量化和传播
- 批准号:
9885918 - 财政年份:2020
- 资助金额:
$ 179.01万 - 项目类别:
Integrating Air Pollution Prediction Models: Uncertainty Quantification and Propagation in Health Studies
整合空气污染预测模型:健康研究中的不确定性量化和传播
- 批准号:
10543137 - 财政年份:2020
- 资助金额:
$ 179.01万 - 项目类别:
Integrating Air Pollution Prediction Models: Uncertainty Quantification and Propagation in Health Studies
整合空气污染预测模型:健康研究中的不确定性量化和传播
- 批准号:
10330579 - 财政年份:2020
- 资助金额:
$ 179.01万 - 项目类别:
Relationship Between Multiple Environmental Exposures and CVD Incidence and Survival: Vulnerability and Susceptibility
多重环境暴露与 CVD 发病率和生存率之间的关系:脆弱性和易感性
- 批准号:
10058839 - 财政年份:2017
- 资助金额:
$ 179.01万 - 项目类别:
Relationship Between Multiple Environmental Exposures and CVD Incidence and Survival: Vulnerability and Susceptibility
多重环境暴露与 CVD 发病率和生存率之间的关系:脆弱性和易感性
- 批准号:
10310468 - 财政年份:2017
- 资助金额:
$ 179.01万 - 项目类别:
相似海外基金
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
- 批准号:
MR/S03398X/2 - 财政年份:2024
- 资助金额:
$ 179.01万 - 项目类别:
Fellowship
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
- 批准号:
2338423 - 财政年份:2024
- 资助金额:
$ 179.01万 - 项目类别:
Continuing Grant
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
- 批准号:
EP/Y001486/1 - 财政年份:2024
- 资助金额:
$ 179.01万 - 项目类别:
Research Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
- 批准号:
MR/X03657X/1 - 财政年份:2024
- 资助金额:
$ 179.01万 - 项目类别:
Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
- 批准号:
2348066 - 财政年份:2024
- 资助金额:
$ 179.01万 - 项目类别:
Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
- 批准号:
AH/Z505481/1 - 财政年份:2024
- 资助金额:
$ 179.01万 - 项目类别:
Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 179.01万 - 项目类别:
EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
- 批准号:
2341402 - 财政年份:2024
- 资助金额:
$ 179.01万 - 项目类别:
Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 179.01万 - 项目类别:
EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
- 批准号:
AH/Z505341/1 - 财政年份:2024
- 资助金额:
$ 179.01万 - 项目类别:
Research Grant