Polymeric materials for biomedical and pharmaceutical applications

我们的研究计划旨在开发具有更好生物相容性和生物接受性的新型高分子材料，用于生物医学和制药应用。天然两亲性化合物如胆汁酸，经过适当的化学修饰，可用于制备新的生物材料，用于组织工程、药物传递、生物分离和生物传感。利用熵驱动开环复分解聚合技术合成了胆汁酸大环，制备了新型可生物降解聚合物。其中一些材料可以表现出有趣的形状记忆特性，并适用于生物医学用途。通过与含有不同化学键的共聚单体共聚，可以调节降解速率和机械性能。各种胆汁酸低聚物将被设计和制备成两亲性口袋，既可以在水介质中溶解疏水化合物，也可以在有机介质中溶解亲水化合物。它们可以作为特殊的药物输送载体和微反应器进行催化。材料将表现出平衡的亲疏水性，并在外部条件的变化中发生有趣和有用的物理性质变化。这些材料的两亲性也将被测试用于催化和生物传感。物理化学研究应该提供与材料的化学结构相关的性质的理解。现代实验技术的光谱学和显微镜被用于表征生物材料。分子在聚合物凝胶和固体中的扩散行为和相互作用将通过各种固态和溶液核磁共振技术进行研究。核磁共振成像技术将有助于阐明不同聚合物基质中的扩散过程。这些材料将根据其预期应用进行测试和优化。我们期望得到的结果对高分子化学和材料科学的基础和实际方面都是有用和重要的。正如我们过去所做的那样，培训高素质的研究人员是研究项目的一个组成部分。

Our research program aims at the development of new polymeric materials with better biocompatibility and bioacceptance for biomedical and pharmaceutical applications. Natural amphiphilic compounds such as bile acids, after proper chemical modification, are used in the preparation of new biomaterials for use in tissue engineering, drug delivery, bioseparation and biosensing. Macrocycles based on bile acids are synthesized to make new biodegradable polymers by the use of entropy-driven ring-opening metathesis polymerization techniques. Some of these materials can manifest interesting shape-memory properties and adaptable for biomedical uses. The degradation rate and mechanical properties will be tuned by copolymerization with comonomers containing different chemical bonds. Various oligomers of bile acids will be designed and prepared to make amphiphilic pockets that can solubilize either hydrophobic compounds in aqueous media or hydrophilic ones in organic media. They may act as special drug delivery vehicles and microreactors for catalysis. The materials will exhibit a balanced hydrophilicity/phobicity and undergo interesting and useful changes in physical properties upon variation of the external conditions. The amphiphilicity of such materials will also be tested for use in catalysis and biosensing. The physico-chemical study should provide an understanding of the properties of materials related to their chemical structures. Modern experimental techniques of spectroscopy and microscopy are used in the characterization of the biomaterials. The diffusion behavior and interaction of the molecules in polymer gels and solids will be studied by various solid state and solution NMR techniques. NMR imaging techniques will help to elucidate the diffusion process in different polymeric matrices. The materials will be tested and optimized for their intended applications. We expect that the results obtained are useful and important to both fundamental and practical aspects of polymer chemistry and materials science. As we have done in the past, the training of highly qualified researchers is an integral part of the research project.