Engineered sugar-based polymers for advanced biomedical applications**********

用于先进生物医学应用的工程糖基聚合物************

• 批准号: 534382-2018
• 负责人: Zhu, Julian
• 金额: $ 1.82万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=669882
• 关键词: Engineered; sugar; based; polymers; advanced

Advanced Polymer Materials Inc. (APM) is a company based in Dorval, QC, manufactures innovative biodegradable and biocompatible specialty polymers to fill the unique R&D needs of customers in pharmaceutical and medical fields. Synthetic sugar group-bearing polymers (glycopolymers) have recently shown interesting potential as alternative replacements of other polymers in drug delivery, the filtration of bacteria such as E. Coli from water through the interactions with sugar-recognizing surface groups. Challenging issues in the synthesis and purification of glycomonomers and polymers limit their commercial availability. Zhu's group at Université de Montréal developed expertise in laboratory scale synthesis and characterization. This 6-month Engage project is proposed to team up APM with Zhu's group in U de M to find solutions to the purification and controllability issues in glycopolymer synthesis, to develop protocols for the synthesis and characterization of a collection of customizable monomers and polymers, and to enlarge the synthetic scale to meet the industrial requirements. Some experiments related to synthetic scaling-up and production will be done in the labs of APM. Pharmaceutical industry in Canada has been strong in R&D and new product development. Through the years, Canada's expertise in this area has often developed through industry-university collaboration. The results will help to improve the competitive edge of the Canadian industry and will bring economic benefits in the form of increased business opportunities and profits, additional employment and tax revenues.

先进聚合物材料公司(APM)是一家总部设在多瓦尔，QC，生产创新的生物降解和生物相容性特种聚合物，以满足客户在制药和医疗领域的独特研发需求。合成糖基聚合物（含糖共聚物）最近显示出有趣的潜力，作为替代其他聚合物在药物输送，细菌，如大肠杆菌的过滤。大肠杆菌通过与糖识别表面基团的相互作用从水中分离。糖共聚单体和聚合物的合成和纯化中存在的问题限制了它们的商业可用性。蒙特利尔大学的Zhu团队在实验室规模的合成和表征方面发展了专业知识。这个为期6个月的Engage项目旨在将APM与朱在U de M的团队合作，寻找糖聚合物合成中纯化和可控性问题的解决方案，开发一系列可定制单体和聚合物的合成和表征方案，并扩大合成规模以满足工业要求。合成放大和生产的相关实验将在APM实验室进行。加拿大制药业在研发和新产品开发方面一直很强。多年来，加拿大在这一领域的专门知识往往是通过产学合作发展起来的。结果将有助于提高加拿大工业的竞争优势，并将带来经济利益，增加商业机会和利润，增加就业和税收。