New opportunities in domino reactions and homogenous gold(I) catalysis

开发新的碳-碳键合成方法对于高效合成在医学、材料科学、生物燃料等领域具有重要应用的分子具有至关重要的意义。此外，由于日益强调可持续性，对有效和尽量减少废物的过程的需要正变得越来越重要。在本研究中，我们将探索多米诺骨牌反应和金催化的新方向，将这些概念融合在一起，开发出强大的、普遍适用于合成重要药物分子的方法。Au（I/III）配合物是一种软路易斯酸，可选择性地配位于p体系，特别是炔和烯。结果，这使得底物p系统缺乏电子，从而有利于亲核试剂的加入。近年来，金的均相催化受到了科学界的广泛关注。金催化在立体选择合成中的应用在很大程度上被忽视。根据实验室的最新进展，我们将探索金催化、多米诺反应及其在复杂天然产物全合成中的应用。

The development of new synthetic methods for the formation of carbon-carbon bonds is of paramount importance for the efficient synthesis of molecules having important application in medicine, material science, biofuels, etc. Furthermore, the ever-increasing emphasis being placed on sustainability, the need for efficient and waste-minimizing processes is becoming more and more important. In this proposal, we will investigate new directions in domino reactions and gold catalysis, merging these concepts for the development of powerful methods of general applicability for the synthesis of medicinally important molecules.Au(I/III) complexes are soft Lewis acids which selectively coordinate to p-systems, notably, alkynes and allenes. As a result, this makes the substrate p-system deficient in electrons thus favoring the addition of nucleophiles. In recent years, homogenous catalysis by gold has received considerable attention by the scientific community. Applications of gold catalysis in stereoselective synthesis have been largely overlooked. Based upon recent development in our laboratory, we will explore gold catalysis, domino reactions and their applications in total synthesis of complex natural products.