Assembling Functional Organic Nanomaterials Using Novel Supramolecular Synthetic Strategies

该计划的主要目标是开发策略和方法，通过自组装在超分子水平上控制分子的行为和功能。为了能够从头开始在纳米尺度上协调物质的组织（即超分子合成），我们将(a)将能够经历分层自组装过程的分子合成为具有预定义尺寸、物理、化学和生物特性的纳米管结构，(b)用各种光谱、成像和建模工具建立它们的自组装，以及(c)研究它们的化学和物理特性。特别是，在过去的五年里，我们已经确定了精心设计的杂双环基序，其特点是在预定义的平面上具有特定的氢键供体和受体组，它们自组装成由18或36个氢键维持的六元超巨环（玫瑰花），然后堆叠形成稳定的玫瑰花纳米管（RNTs），具有前所未有的化学，物理和生物特性。

This program's main objective is to develop strategies and methods to control the behavior and function of molecules at the supramolecular level via self-assembly. To be able to orchestrate the organization of matter at the nanoscale from the ground up (i.e. supramolecular synthesis), we will (a) synthesize molecules that are capable of undergoing a hierarchical self-assembly process into nanotubular architectures with predefined dimensions, physical, chemical, and biological properties, (b) establish their self-assembly with a variety of spectroscopic, imaging, and modeling tools, and (c) investigate their chemical and physical properties. In particular we have over the past five years established that carefully designed heterobicyclic motifs featuring specific sets of hydrogen bond donors and acceptors in pre-defined planes self-assemble into six-membered supermacrocycles (rosettes) maintained by 18 or 36 H-bonds, which then stack to form stable rosette nanotubes (RNTs) with unprecedented chemical, physical and biological properties.