Regulation of Leukocyte-Endothelial Interactions

在脊椎动物中，白细胞通过提供对细菌、真菌和病毒感染的保护，在免疫系统中发挥重要作用。白血球在全身巡逻，寻找感染的迹象。这种免疫细胞监测涉及白细胞和血管内壁细胞之间的相互作用。白细胞通过不同的信号被招募到损伤区域，特别是被称为趋化因子的分子。在趋化因子家族中，有一种成员是Fractalkine，它位于血管衬里细胞的表面，既能吸引白细胞，又能将它们物理地附着在血管上。

In vertebrate animals, white blood cells play an important role in the immune system by providing protection against bacterial, fungal, and viral infections. White blood cells patrol throughout the body looking for signs of infection. This immune cell surveillance involves interactions between white blood cells and the cells lining blood vessels. White cells are recruited to areas of injury by different signals, especially molecules called chemokines. Among the family of chemokines, one member, fractalkine, is found on the surface of cells lining blood vessels, and both attracts white cells and physically attaches them to blood vessels.