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Isolation and characterization of plant insulators

Isolation and characterization of plant insulators
植物绝缘体的分离和表征
批准号:
2869-2011
负责人:
Johnson, Douglas
金额:
$1.75万
依托单位:
依托单位国家:
加拿大
项目类别:
Discovery Grants Program - Individual
财政年份:
2014
资助国家:
加拿大
项目状态:
已结题
起止时间:
2014-01-01 至 2015-12-31

项目摘要

项目成果

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中文摘要
翻译
绝缘子是能够阻断不适当或不需要的增强子-启动子通讯(增强子阻断剂活性)和/或防止抑制性染色质扩散到活性染色质(屏障活性)的DNA元件。它们的作用由识别它们的蛋白质介导,导致许多蛋白质的募集,并最终组装成“绝缘体”,即所提出的“功能单位”。因此,绝缘子代表了转录控制的另一个水平,他们的研究代表了了解基因调控的基本,普遍机制的机会。
英文摘要
Insulators are DNA elements that are able to block inappropriate or unwanted enhancer-promoter communication (enhancer blocker activity) and/or prevent the spread of repressive chromatin into active chromatin (barrier activity). Their action is mediated by protein(s) that recognize them leading to the recruitment of many proteins and ultimately the assembly "insulator bodies" the proposed "functional unit". Thus insulators represent an additional level of transcriptional control and their study represents an opportunity to understand a basic, universal mechanism of gene regulation.
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Isolation and characterization of plant insulators
  • 批准号:
    2869-2011
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $1.75万
  • 财政年份:
    2015
  • 负责人:
    Johnson, Douglas
  • 依托单位:
Metabolic engineering of cannabis biopathways
  • 批准号:
    485742-2015
  • 项目类别:
    Engage Grants Program
  • 资助金额:
    $1.82万
  • 财政年份:
    2015
  • 负责人:
    Johnson, Douglas
  • 依托单位:
Isolation and characterization of plant insulators
  • 批准号:
    2869-2011
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $1.75万
  • 财政年份:
    2013
  • 负责人:
    Johnson, Douglas
  • 依托单位:
Isolation and characterization of plant insulators
  • 批准号:
    2869-2011
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $1.75万
  • 财政年份:
    2012
  • 负责人:
    Johnson, Douglas
  • 依托单位:
海外基金