B-S chemistry: investigating the Thioboration reaction

我们的研究计划分为两个主要部分：(i)开发用于硼化反应的新化合物（将E- b键添加到有机碎片上，其中E =氢，硼，硫，硒，锡等）和（ii）开发生物活性硼和金属化合物。毫无疑问，我在本科院校的研究中最重要的影响是HQP的培训，即建立一个安全、有趣和富有成效的实验室，让学生体验化学研究。这一建议涉及到制造和研究含有B-S键的新化合物，其中硼基团来源于合成有用的硼酸酯。B-S化合物的反应性将在使用过渡金属催化剂和微波介导条件下与许多有机底物进行研究。所有新化合物都将被测试潜在的抗真菌性能，因为我们正在寻找开发新的生物活性硼化合物。

The aim of our research program is divided into two major sections: (i) the development of new compounds to be used for the borylation reaction (addition of E-B bonds to organic fragments, where E = hydrogen, boron, sulfur, selenium, tin, etc) and (ii) the development of biologically-active boron and metal compounds. Without question, the most significant impact I can make in research at an undergraduate institution involves the training of HQP, whereby establishing a safe, fun, and productive laboratory where students come to experience chemical research. This proposal deals with making and study new compounds containing a B-S bond, where the boron group is derived from synthetically useful boronate esters. Reactivity of B-S compounds will be investigated with a number of organic substrates with, and without, the use of transition metal catalysts and microwave mediated conditions. All new compounds will be tested for potential antifungal properties as we search to develop new biologically active boron compounds.