New opportunities in domino reactions and homogenous gold(I) catalysis

用于形成碳-碳键的新合成方法的开发对于有效合成在医学、材料科学、生物燃料等中具有重要应用的分子是至关重要的。此外，对可持续性的日益强调，对高效和废物最小化过程的需求变得越来越重要。在这个提议中，我们将研究多米诺骨牌反应和金催化的新方向，合并这些概念的发展强大的方法的普遍适用性的合成medically重要的molecules.Au（I/III）配合物是软刘易斯酸选择性地协调p-系统，特别是，炔和联烯。因此，这使得底物p-系统缺乏电子，从而有利于亲核试剂的加入。 近年来，金的均相催化作用受到科学界的广泛关注。金催化在立体选择性合成中的应用一直被忽视。本文将结合本实验室的最新研究成果，探讨金催化、多米诺反应及其在复杂天然产物全合成中的应用。

The development of new synthetic methods for the formation of carbon-carbon bonds is of paramount importance for the efficient synthesis of molecules having important application in medicine, material science, biofuels, etc. Furthermore, the ever-increasing emphasis being placed on sustainability, the need for efficient and waste-minimizing processes is becoming more and more important. In this proposal, we will investigate new directions in domino reactions and gold catalysis, merging these concepts for the development of powerful methods of general applicability for the synthesis of medicinally important molecules.Au(I/III) complexes are soft Lewis acids which selectively coordinate to p-systems, notably, alkynes and allenes. As a result, this makes the substrate p-system deficient in electrons thus favoring the addition of nucleophiles. In recent years, homogenous catalysis by gold has received considerable attention by the scientific community. Applications of gold catalysis in stereoselective synthesis have been largely overlooked. Based upon recent development in our laboratory, we will explore gold catalysis, domino reactions and their applications in total synthesis of complex natural products.