Analysis of evolutionary mechanisms in signaling networks

我们目睹了生物科学新范式的兴起，它将生物网络置于科学研究的焦点。作为细胞“CPU”的信号网络尤为重要。这些信号通路严格调节细胞过程，并对外界刺激做出精细的反应。在我们的进化史上，越来越复杂的信号网络的出现使得高等生物的复杂性不断增加。这些网络是如何在我们的进化史中出现的，迄今为止还没有经过严格的研究，其中的机制也是未知的。然而，很明显，信号网络已经适应了不同的进化压力，并经历了广泛的重新布线，从而实现了进化进程。

We have witnessed the rise of a new paradigm in bioscience, which put biological networks in the focus of scientific study. Of particular importance are signaling networks as the "CPU" of cells. These signaling pathways tightly regulate cellular processes and are finely tuned to respond to external stimuli. The rise of increasingly sophisticated signaling networks in our evolutionary history enabled the increasing complexity of higher organisms. How these networks arose in our evolutionary history has thus far not undergone rigorous study and the mechanisms at play are unknown. However, it is clear that signaling networks have been adapting to different evolutionary pressures and have undergone extensive rewiring, thereby enabling evolutionary progress.