Sample pre-concentration platform based on laminar flow capacitive ion guide for mass spectrometry

将与生物分析化学和生物医学研究领域的专家一起对连续电容离子引导装置进行市场评估。电容式去离子技术（CDI）因其稳定、节能、低成本等特点，已成为低、中含盐量水净化技术中最有前途的一种。目前所有的CDI设备都采用两步操作，电极充电（水去离子化）步骤和电极放电（离子释放，电极再生）步骤。我们提出的连续层流电容离子导流装置是新一代的电容离子导流装置，它消除了传统CDI装置的两步操作，从而大大提高了效率，具有更广泛的新用途。在我们的模拟装置操作中，我们已经证明了带电物质可以连续地定向到不同的通道中。在这些侧通道中，体积越小，带电物质的浓度就越高。该富集操作可用于样品预浓缩，用于超痕量分析物，用于通过质谱分析或任何其他分析检测器分析生物重要分子。

Market assessment for continuous capacitive ion guide apparatus will be conducted with experts in the field of bioanalytical chemistry and biomedical research. Capacitive deionization (CDI) has become one of the most promising desalination technologies for purifying water with low to moderate amount of salt, because it's robust, energy efficient, and low cost properties. Currently all CDI apparatus use a two-step operation, the electrode charging (deionization of water) step, and the electrode discharge (ion release, electrode regeneration) step. The continuous laminar flow capacitive ion guide apparatus we proposed is a new generation of capacitive ion guide that eliminated the need of the two step operation of the traditional CDI devices, therefore significantly increased the efficiency and makes it useful in wider range of new applications. In our simulated device operations we have demonstrated that charged species can be continuously directed into separate channels. With a smaller volume in these side channels the concentration of the charged species can be significantly enriched. This enrichment operation can be used for sample pre-concentration for ultra trace analytes for biologically important molecules to be analysed by mass spectrometry or any other analytical detectors.