Light emitting diodes and pulsing systems for next generation optogenetic tools

Mightex是一家总部位于多伦多的生物光子学公司，对光遗传学领域有着浓厚的兴趣。这是一个快速发展的新领域，利用光来控制活体动物体内的转基因目标（“光遗传工具”）。光遗传学方法在理解复杂的神经系统疾病，如精神分裂症和自闭症方面的力量，在科学界非常令人兴奋。Mightex希望适应或开发技术，以跟上下一代光遗传学工具的步伐。伍利实验室正在开发这些光遗传学工具（称为“光药物”），用于光控制对大脑中特定蛋白质的作用。该提案旨在将Woolley实验室的研究人员和Mightex的工程师聚集在一起，修改和优化用于控制光药物的Mightex BioLED和智能推进设备。

Mightex is a Toronto-based biophotonics company with a strong interest in the field of optogenetics. This is a new and rapidly developing field in which light is used to control genetically modified targets ("optogenetic tools") inside living animals. There is great excitement in the scientific community about the power of optogenetic approaches for understanding complex neurological diseases such as schizophrenia and autism. Mightex wishes to adapt or develop technology to keep pace with next generation optogenetic tools. The Woolley lab is developing these optogenetic tools (called "opto-drugs") for light controlled action on specific proteins in the brain. This proposal seeks to bring together researchers in the Woolley lab and engineers from Mightex to modify and optimize Mightex BioLED and Intellipusling equipment for the control of opto-drugs.