Further Optimization and scale-up of high-yielding stereoselective methodologies for the synthesis of Active Pharmaceutical Agents (API)

与Alphora Research的拟议合作项目涉及开发一组称为软海绵素多环大环内酯的化学化合物前体的合成工艺，这些化合物有可能作为抗癌药物。这些抗肿瘤物质与软海绵素B有关，软海绵素B是一种从海绵中分离出来的天然产物。加拿大卫生部和FDA最近批准了用于治疗某些转移性乳腺癌的全合成类似物艾日布林;然而，生产工艺对这种物质和相关物质还不是有效的。在我们最近的参与补助金之后，我们正在继续努力改进制备这组具有医学重要性的化合物的一些步骤的方法。

The proposed collaborative project with Alphora Research involves the development of synthetic processes for manufacturing precursors for a group of chemical compounds called halichondrin polycyclic macrolides, which have potential as cancer drugs. These anti-tumour substances are related to halichondrin B, a natural product that was isolated from a marine sponge. Health Canada and the FDA have recently approved the fully synthetic analog eribulin for treatment of certain metastatic breast cancers; however, the manufacturing process is not yet efficient for this and related substances. Following up with our recent Engage Grant, we are continuing our efforts in improving the methodologies for some of the steps in the preparation of this medicinally important group of compounds.