Development of a stilbene-enriched icewine grape skin extract

酿酒葡萄是白藜芦醇和各种有益健康的相关分子的天然来源。这类分子的主要类群之一被称为二苯乙烯。这些有益分子主要在葡萄皮中产生。在秋季的过程中，葡萄中积累了芪。此外，研究人员已经证明，通过将葡萄暴露在紫外线下，可以刺激葡萄在收获后产生更多的这些分子。葡萄皮是冰酒生产中的废物。目前，葡萄皮不仅没有价值，而且曝光它们的代价也很高。考虑到葡萄皮可能是二苯乙烯的最佳天然来源，我们建议通过从葡萄皮废料中提取二苯乙烯来提取价值。从秋季收获的冰酒葡萄开始，我们将使用重复紫外线刺激的方案来提高二苯乙烯的产量。然后我们将把果皮从葡萄果肉中分离出来。葡萄果肉可用于酿酒。在这里，我们将重点开发一种方法，以最大限度地从皮肤中提取芪。然后，我们将验证提取的二苯乙烯的生物活性。我们希望这项工作能带来冰酒葡萄的新产品（或产品线），这样葡萄酒生产的葡萄果肉就不会受到不利影响（事实上，它也将被苯乙烯增强），并且从皮中获得重要的价值，而皮目前是废物。这将在加工、包装和销售我们从冰酒葡萄中提取的富含二苯乙烯的新产品方面带来新的就业机会。

Wine grapes are a natural source of resveratrol and a variety of related molecules with health benefits. One of the main groups of such molecules is called stilbenes. These beneficial molecules are produced primarily in grape skins. Over the course of the fall season there is an accumulation of stilbenes in grapes. In addition, researchers have shown that grapes can be stimulated post-harvest to produce even more of these molecules by exposing the grapes to UV light. Grape skins are a waste product in ice wine production. Not only is there no value currently associated with the grape skins, but it is also expensive to expose of them. Given that the skins are probably the best natural source of stilbenes, we propose to extract value from the grape skin waste product by extracting the stilbenes from them. Starting with fall harvest ice wine grapes, we will use a protocol of repeated UV stimulation to enhance production of stilbenes. We will then separate skins from the grape pulp. Grape pulp can be used in wine production. Here we will focus on developing a method to maximally extract stilbenes from the skins. We will then verify the biological activities of the extracted stilbenes. We expect this work to lead to a new product (or line of products) from ice wine grapes, such that the wine-producing grape pulp is not adversely affected (indeed, it will also be stilbene-enhanced) and significant value is captured from the skins, which are currently a waste product. This will in turn lead to new jobs in processing, packaging and selling our new stilbene-rich products from ice wine grapes.