Feasibility of using direct mechanical micromachining to build microfluidic cartridges for capillary driven Point of Care diagnostic devices

血液分析是诊断患者的医学状况的重要参数。大多数血液检查在当地医院进行，需要安排时间和等待时间。另一方面，手持式血液分析仪通过在患者的接触点附近提供这些血液测试而具有很大的益处。这将有助于例如护理人员、重症监护室人员或救灾人员在现场进行血液测试并做出相应反应。尽管存在许多手持式系统，但它们中没有一个联合收割机结合电化学和光谱学方法。通过该提案，我们将为ChroMedX Corp.开发一种适用于在其手持式分析仪中对血液样本进行光学和化学测量的一次性检测盒做出贡献。将使用具有成本效益的精密制造技术来制作这种一次性药筒的原型，以便进行大规模生产。这将有助于该公司到2020年达到380亿美元的目标全球市场。该项目将使ChroMedX能够开发原型并验证其分析。该项目还将培养学生的跨学科技能，与工业合作伙伴的互动将是对学生的良好培训。

Blood analysis is an important parameter to diagnose a medical condition of a patient. Most blood tests are carried out in a local hospital which requires scheduling and waiting time. A hand held blood analyzer on the other hand has much benefit by providing these blood tests near the point of contact of a patient. This will help for example paramedics, intensive care unit personnel or disaster relief personnel to perform blood test on the spot and respond accordingly. Although many handheld systems exist none of them combine electrochemical and optical spectroscopy methods. With this proposal, we will contribute towards the development of a disposable cartridge for ChroMedX Corp. that is suitable for performing optical and chemical measurements of a blood sample in their hand held analyzer. A cost effective precision manufacturing technique will be used to prototype such disposable cartridges for mass production. This will help the company to reach their targeted global market of $38 billion by year 2020. This project will enable ChroMedX to develop prototypes and validate their assays. This project will also develop interdisciplinary skills in the students and the interaction with industrial partner will be an excellent training for the students.