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Understanding the Effects of Histone Modifications and their Symbiotic Role with Additional Genetic Aberrations in the Development of Pediatric Diffuse Intrinsic Pontine Glioma

Understanding the Effects of Histone Modifications and their Symbiotic Role with Additional Genetic Aberrations in the Development of Pediatric Diffuse Intrinsic Pontine Glioma
了解组蛋白修饰的影响及其与额外遗传畸变在儿科弥漫性内源性脑桥胶质瘤发展中的共生作用
批准号：
331348
负责人：
Ryall Scott T
金额：
$1.27万
依托单位：
University of Toronto
依托单位国家：
加拿大
项目类别：
Studentship Programs
财政年份：
2014
资助国家：
加拿大
项目状态：
已结题
起止时间：
2014-12-01 至 2015-12-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=331348&lang=en
关键词：
Diffuse Intrinsic Pontine Glioma Gene Expression H3.3k27m Histones Inducible Methylation Status Mutation Synergy Targeted Therapy Transformation Potential

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中文摘要
翻译
脑肿瘤是儿童癌症相关死亡的主要原因，其中最致命的是发生在脑干的弥漫性固有脑桥胶质瘤（DIPG）。尽管经过几十年的研究，对DIPG及其结果仍没有有效的治疗方法
英文摘要
Brain tumors are the leading cause of cancer-related death in children, the most deadly of which is diffuse intrinsic pontine glioma (DIPG) which arises in the brainstem. Despite decades of research there is no effective treatment for DIPG, and its outcom
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