A study of ozonolysis reactions for lipid transformations by mass spectrometry

臭氧分解涉及臭氧与不饱和有机化合物的反应。 半个多世纪以来，它一直被用作测定天然产物和脂质中双键位置的方法。 最近，脂质的臭氧分解已经与电喷雾质谱法相结合，从而允许直接观察臭氧分解产物。 臭氧分解也被开发为将植物油中存在的不饱和脂肪酸转化为用于制造聚氨酯的称为“多元醇”的化合物的过程的一部分。 从可再生资源生产的多元醇，如菜籽油，可以取代石化工业生产的数百万吨多元醇中的一部分，用于制造各种材料，包括刚性和弹性泡沫，涂料，粘合剂和塑料。 这个发现计划是对天然油脂臭氧分解的基础研究。 臭氧分解将在实验室和中试规模的反应器中进行，以及在现场的质谱仪离子源，以监测臭氧分解中间体和它们的进一步反应。 对商品脂质的臭氧分解及其可获得的产品的深入了解将为新型生物多元醇的开发提供方向，这对加拿大农民和化学品制造商来说是一个令人兴奋的前景，具有巨大的潜力。 该计划的另一个目标是进一步开发臭氧分解/质谱法在健康，农业和营养方面重要的脂质应用的分析潜力。

Ozonolysis involves the reaction of ozone with unsaturated organic compounds. It has been used as a method to determine double bond positions in natural products and lipids for more than half a century. Recently, the ozonolysis of lipids has been combined with electrospray mass spectrometry, thereby allowing direct observation of the ozonolysis products. Ozonolysis is also being developed as part of a process to convert the unsaturated fatty acids present in vegetable oils into compounds known as "polyols" which are used in the manufacture of polyurethanes. Polyols produced from renewable resources, such as canola oil, could replace some of the millions of tonnes of polyols produced by the petrochemical industry for making a wide range of materials including rigid and elastic foams, coatings, adhesives and plastics. This Discovery program is a fundamental study of the ozonolysis of natural oils and fats. Ozonolysis will be performed in laboratory and pilot scale reactors, as well as in situ in a mass spectrometer ion source in order to monitor the ozonolysis intermediates and their further reactions. Enhanced understanding of the ozonolysis of commodity lipids and the products which can be obtained from them will provide direction for new bio-polyol development, an exciting prospect with enormous potential for Canadian farmers and chemical manufacturers. An additional objective of this program is to further develop the analytical potential of ozonolysis/mass spectrometry for lipid applications of importance in health, agriculture and nutrition.