Separate and combined effects of temperature and oxygen on neuromuscular function

在过去的十年中，高体温已被认为是自愿运动能力和耐力下降的直接原因。然而，体温影响运动能力的机制仍然是争论的主要来源。其中一个研究领域集中在温度对我们肌肉的影响上。较高的体温似乎会直接降低大脑招募和激活肌肉的能力。然而，较高的肌肉温度本身或较高的皮肤温度也会降低对运动的耐受性。因此，研究这些不同的温度输入如何结合联合收割机来影响肌肉功能是很重要的。与此同时，温度变化也会影响血液流量和氧气输送到大脑和肌肉的量，而大脑或肌肉可用的氧气对实际肌肉功能有着强大的影响。因此，为了了解温度对肌肉功能的实际影响，研究什么是由于氧气变化以及什么是由于温度变化变得很重要。这是拟议研究的主要目标。 拟议研究计划的主题和主要目标包括： 1. 通过控制全身和局部肌肉温度，了解局部和全身温度对肌肉功能和运动能力的相对重要性。 2. 通过操纵大脑和肌肉的温度和氧气供应，了解每一个对肌肉功能的单独和综合影响。

Over the past decade, a high body temperature has become recognized as a direct cause of decreased voluntary exercise capacity and tolerance. However, the mechanism by which body temperature influences exercise capacity remains a major source of debate. One area of research has focused on the effects of temperature on our muscles. Higher body temperature appears to directly reduce the brain's ability to recruit and activate muscles. However, higher muscle temperature by itself or a higher skin temperature can also reduce tolerance to exercise. Therefore, it is important to study how these different temperature inputs combine to affect muscle function. At the same time, temperature changes also affect the amount of blood flow and oxygen delivery to the brain and muscles, and the oxygen available to the brain or muscles is a powerful influence on actual muscle function. Thus, in order to understand the actual effects of temperature on muscle function, it becomes important to study what is due to oxygen changes and what is due to temperature. This is the main goal of the proposed research. The themes and primary objectives of the proposed research program include: 1. Through manipulating whole-body and local muscle temperature, understanding the relative importance of local and overall body temperature on muscle function and exercise capacity. 2. Through manipulating temperature and oxygen availability at the brain and muscles, understanding the separate and combined effects of each on muscle function.