Hybrid Molecular Imaging in the Diagnosis of Heart Disease

问题背景：我们团队发现了一种名为GHS-R的分子，它可能是心脏病的标志。我们 我想开发一种技术，以非侵入性的方式检测GHS-R，这将有助于心脏病专家正确地 在心脏病的早期阶段诊断。这项技术是两种诊断成像方法的组合或混合： 正电子发射断层扫描(PET)，它将检测GHS-R，以及磁共振成像(MRI)，它检测 心脏功能的改变。将这两种成像方法结合起来将产生一种非常强大的技术，可以 同时测量心脏的分子和生理变化。 研究计划的目的：我们将开发PET-MRI混合成像，通过PET和心脏检测GHS-R的变化 同时进行MRI检查。这将使心脏病专家能够发现心力衰竭的早期阶段。 研究项目简介：我们将首先在心脏病小鼠模型上测试GHS-R的PET成像。然后 我们将在心脏病的大型动物模型中测试PET-MRI技术，因为这是使用 人类的技术。最后，我们将与心脏病专家合作，使用PET-MRI方法来检测GHS-R和心脏 心脏疾病患者的功能。 我们的研究将如何改善加拿大人的健康：有很大一部分人患有充血心脏 失败了。这些患者占大多数急诊医院入院患者的很高比例，通常需要几个 招生。在早期时间点检测心脏病的能力，并洞察疾病机制 可能会促进限制疾病进展的新干预措施，为拟议研究的应用带来了巨大的希望。

Brief background of issue: Our group has discovered a molecule, called GHS-R, that may be a marker of heart disease. We would like to develop a technology to detect GHS-R in a non-invasive manner that will help cardiologists in properly diagnosing heart disease in its early stages. The technology is a combination, or hybrid, of two diagnostic imaging methods: positron emission tomography (PET), which will detect GHS-R, and magnetic resonance imaging (MRI), which detects changes in the function of the heart. Combining these two imaging methods will result in a very powerful technology that can measure both molecular and physiological changes in the heart at the same time. Objective of the research proposal: We will develop PET-MRI hybrid imaging to detect changes in GHS-R by PET and heart function by MRI at the same time. This will enable cardiologists to detect very early stages of heart failure. Brief description of research project: We will first test the PET imaging of GHS-R in a mouse model of heart disease. Then we will test the PET-MRI technique in a large animal model of heart disease, because this is the next step to using the technique in humans. Finally, we will work with cardiologist to use the PET-MRI method to detect both GHS-R and heart function in patients with heart disease. How our research will improve the health of Canadians: There is a large segment of the population that has congestive heart failure. These patients represent a high percentage of admitted patients to most acute care hospitals, often requiring several admissions. The ability to detect heart disease at an early point in time, and to gain insight into disease mechanisms that may promote new interventions to limit disease progression hold great promise for the application of the proposed research.