Silver Oxysalt Impregnated Hydrogels

银氧盐®是一种新型抗菌银技术，但它对湿气和水分敏感。很难做到 将银氧盐®应用于任何水凝胶基质，因为配方必须在水中停留很长时间 使用前的介质(装运期间等)。该项目将通过封装来克服此限制 也可用作水凝胶的聚合物中的银氧盐®。Exciton之前的工作主要集中在 使用可生物降解的聚合物(聚乳酸和聚己内酯)包裹银氧盐® 为明确提高其稳定性(即，由于暴露在湿气中而减少降解)。至 到目前为止，还没有为此目的使用水凝胶材料的工作。由于应用范围广泛， 水凝胶，人们认为开发这一平台技术将允许新产品的开发。在……里面 特别是，由于隐形眼镜制造商在艾伯塔省的存在，这项工作的一个应用领域是 通过开发水凝胶配方，将银氧盐®性能转化为隐形眼镜使用。 Exiton Technologies是一家加拿大先进的研发和制造公司 专门从事医用抗菌银技术的商业化。激子 科技公司正在通过获得专利的ExSalt®平台提供更有效的抗菌银技术 与竞争产品相比，成本要低得多。在FDA的批准下，两种ExSalt®伤口敷料现在 与竞争对手的抗菌产品相比，可提供广泛的好处。ExSalt®含银含氧盐 技术安全地将含有所有三种化学状态(+1，+2，+3)的最活跃的银化合物提供给 预防感染，清除细菌。但是，银氧盐®的稳定性是一个主要的持久性问题，它 由于对水分/水的敏感性，银氧盐®的应用受到限制。

Ag oxysalts® is a novel antimicrobial silver technology but it is moisture and water sensitive. It is difficult to apply Ag oxysalts® to any hydrogel matrix due to the long time that the formulation must stay in aqueous medium prior to use (ie during shipping, etc). This project will overcome this limitation through encapsulating the Ag oxysalts® in polymers that can also be used as hydrogels. Previous work from Exciton has focused upon the encapsulation of Ag oxysalts® using biodegradable polymers (polylactic acid and polycaprolactone) for the express purpose of enhancing its stability (ie. decrease in degradation due to exposure to moisture). To date, no work has been done using hydrogel materials for this purpose. Due to the wide range of application of hydrogels, it is thought that developing this platform technology will allow for new product development. In particular, due to the presence of a contact lens manufacturer in Alberta, one area of application for this work is translating Ag oxysalts® capabilities to contact lens use through developing hydrogel formulations. Exciton Technologies is a Canadian advanced research, development, and manufacturing company specializing in the commercialization of antimicrobial silver technology for medical applications. Exciton Technologies is delivering a more effective antimicrobial silver technology through patented exsalt® platform at a significantly lower cost to competing products. With FDA approval, two exsalt® wound dressings are now available with extensive benefits over competitive antimicrobial products. Exciton's exsalt® silver oxysalts technology safely delivers the most active compound of silver containing all three chemical states (+1,+2,+3) to prevent infection and eliminate bacteria. But, stability of Ag oxysalts® is a major persistent problem and it limits the applications of Ag oxysalts® due to moisture/water sensitivity.