Controlled release of functional lactoferrin from non-animal sourced matrix materials.

从非动物源基质材料中控制释放功能性乳铁蛋白。

• 批准号: 538216-2019
• 负责人: Unsworth, Larry
• 金额: $ 1.82万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=680399
• 关键词: Controlled; release; functional; lactoferrin; non

Improving the bioavailability of drugs and natural health products is a major hurdle in the nutraceutical industry. Despite the obvious health benefits, several candidate molecules are not pursued due to the inability of current delivery techniques to ensure their bioavailability, solubility and absorption. In particular, we are interested in controlling lactoferrin (a milk heme protein) release. Moreover, the industry is hindered by the community of users who want to avoid traditional matrices for releasing drugs (ie. polymers) for a more bio/natural material. Professor Unsworth has extensive and critical experience working with matrices composed of synthetic peptides from non-animal sources, as well as the controlled release of proteins. Thus, we are working together to develop a system to control the functional release of lactoferrin so as to develop a functional product.

提高药物和天然保健品的生物利用度是营养保健品行业的主要障碍。尽管有明显的健康益处，但由于目前的递送技术无法确保其生物利用度、溶解度和吸收，因此没有追求几种候选分子。特别是，我们感兴趣的是控制乳铁蛋白（牛奶血红素蛋白）的释放。此外，该行业受到用户群体的阻碍，这些用户希望避免传统的药物释放基质（即，聚合物）用于更生物/天然的材料。Unsworth教授在处理由非动物来源的合成肽组成的基质以及蛋白质的控释方面拥有丰富而重要的经验。因此，我们正在共同努力开发一种控制乳铁蛋白功能释放的系统，以开发功能性产品。