Technology for clean and scalable synthesis of metal-organic frameworks

所提出的申请旨在将最近开发的用于微孔金属有机框架（M0 F）的克级制造的新的清洁技术（US 62/119，436）按比例扩大到用于制造多种类型的M0 F的>10千克/天的分批工艺。这种经过验证的清洁制造工艺将为建立和合并一家名为Q-MOF的初创公司提供基础，该公司将成为第一家在商业上为学术研究应用提供复杂且廉价的MOF的公司，以及气体净化，氢燃料电池，甲烷和乙炔储存，二氧化碳封存和催化的商业机会。虽然少数制造商最近开始商业化地提供数量非常有限的MOFs，但这些材料的价格很高（每公斤> 12，000美元）。此外，制造这些材料的现有方法的特征在于高环境影响和安全风险，并且涉及腐蚀性起始材料和苛刻的反应条件。我们最近获得专利的技术允许从众所周知的安全试剂中廉价，简单和环保地合成各种各样的MOFs。这项拟议中的研究将使我们能够扩大清洁和廉价的MOF制造技术，并扩大可获得的MOF产品组合，将使我们能够建立一家财政部制造公司，通过提供大量产品来满足新兴研究和工业应用市场的需求（10- 100 kg）的MOF产品，价格是目前的50%或更低。我们最初的预期市场是吸附剂，重点是燃料电池技术，但我们也旨在为研究用户提供具有各种应用的产品。

The proposed application aims to scale up a recently-developed new and clean technology (US 62/119,436) for gram-scale manufacturing of microporous metal-organic frameworks (MOFs) into a >10 kilogram/day batch process for manufacturing multiple types of MOFs. This proven clean manufacturing process will provide a foundation to establish and incorporate a start-up company, called Q-MOF, which will be the first to commercially provide sophisticated and inexpensive MOFs for applications in academic research, as well as commercial opportunities in gas purification, hydrogen fuel cells, storage of methane and acetylene, carbon dioxide sequestration, and catalysis. Although a small number of manufacturers have recently begun commercially offering a very limited number of MOFs, these materials are available only at exorbitant cost (>$12,000 per kg). As well, the existing processes through which these materials are made are characterized by high environmental impact and safety risks, and involve corrosive starting materials and harsh reaction conditions. Our recently patented technology allows for the inexpensive, simple and environmentally-friendly synthesis of a wide diversity of MOFs from well-known and safe reagents. The proposed research, which will allow us to scale-up our clean and inexpensive MOF manufacturing technology and expand the portfolio of accessible MOF products, will enable us to establish a MOF manufacturing company that will meet the needs of the emerging research and industrial applications markets by providing large amounts (10-100kg) of MOF products for a price that is 50% or less than what is currently offered.Our initial expected market is adsorbents, with a focus on fuel cell technology, but we also aim to provide products to research users with a variety of applications.