Investigation of ulcer disease in Atlantic Salmon

溃疡病是加拿大东海岸水产养殖中使用抗生素的主要原因。换句 在一些国家，这种情况是由Moritella viscosa引起的;然而，在加拿大， 从有和没有分离M的病变中分离出来。粘滞和病变发生在更温暖 温度。传闻报告表明，这种疾病的死亡率正在上升， 这是由于治疗抗性、毒性增加、宿主免疫力降低、暴露增加或 这些因素的结合。确定这种疾病的危险因素和管理策略是 需要提高行业的可持续性。到目前为止，还没有出版的摘要， 加拿大溃疡病的流行病学。这一基本信息对于发展关于以下问题的假设至关重要： 控制和预防策略。该项目的总体目标是更好地了解 加拿大东海岸大西洋鲑鱼养殖场的溃疡病。具体来说，我们的目标是：1）描述 在围栏和农场水平上与特定环境和畜牧业因素有关的疾病爆发，以及 2)评估过去2年中抗生素对该病原体的治疗效果。我们还将调查 加拿大分离的M. viscosa在实验室条件下，以确定我们是否可以模拟该领域 与溃疡病相关的观察结果。这项研究将提供一个系统的评估和描述 溃疡病的流行病学，这将为治疗和预防提供科学依据 战略布局这项研究的初步结果将成为与联合国开发计划署（开发署）开展一个更大的合作项目的基础。 水产养殖业在未来一年内评估这种疾病的不同控制策略。

Ulcer disease is the primary reason for antibiotic usage in aquaculture on the East coast of Canada. In other countries this condition is caused by Moritella viscosa; however, in Canada other bacterial pathogens have been isolated from lesions with and without the isolation of M. viscosa and the lesions occur at much warmer temperatures. Anecdotal reports suggest mortality from this disease is increasing and it is unknown whether this is due to treatment resistance, increased virulence, reduction in host immunity, increased exposure, or a combination of these factors. Identification of risk factors and management strategies for this disease are needed to improve the sustainability of the industry. To date there are no published summaries of the epidemiology of ulcer disease in Canada. This basic information is essential for developing hypotheses on control and prevention strategies. The overall goal of this project is to better understand the epidemiology of ulcer disease on Atlantic salmon fish farms on the East Coast of Canada. Specifically we aim to 1) describe disease outbreaks with respect to specific environmental and husbandry factors at the pen and farm level, and 2) assess antibiotic treatment efficacy for this pathogen over the last 2 years. We will also investigate exposure to a Canadian isolate of M. viscosa under laboratory conditions to determine if we can mimic the field observations associated with ulcer disease. This research will provide a systematic assessment and description of the epidemiology of ulcer disease, which will provide science-based evidence for treatment and prevention strategies. The preliminary findings from this study will be the basis for a larger, collaborative project with the aquaculture industry within the next year to evaluate different control strategies for this disease.