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Fundamental Molecular Mechanisms of DNA Damage

Fundamental Molecular Mechanisms of DNA Damage
DNA 损伤的基本分子机制
批准号:
RGPIN-2015-06247
负责人:
Loppnow, Glen
金额:
$2.04万
依托单位:
依托单位国家:
加拿大
项目类别:
Discovery Grants Program - Individual
财政年份:
2015
资助国家:
加拿大
项目状态:
已结题
起止时间:
2015-01-01 至 2016-12-31

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中文摘要
翻译
DNA和RNA是腺苷(A)、胞苷(C)和胍(G)核苷酸的线性低聚物,尿苷(U)或胸苷(T)分别是RNA和DNA中的第四个核苷酸。在DNA中,碱基之间的氢键形成了标志性的双链B型螺旋,C与G配对,A与T配对。碱基电子态之间的重叠和相互作用导致了减色、激子分裂和超快(亚PS)电子激发态弛豫,导致了预测DNA的化学和光物理行为的困难。
英文摘要
DNA and RNA are linear oligomers of adenosine (A), cytidine (C), and guanidine (G) nucleotides, with either uridine (U) or thymidine (T) as the fourth nucleotide in RNA and DNA, respectively. In DNA, hydrogen bonding between nucleobases on two oligomeric strands forms the iconic double-stranded B-form helix, with C pairing with G and A pairing with T. The consequent overlap and interactions between the nucleobase electronic states results in hypochromism, exciton splitting and ultrafast (sub-ps) electronic excited-state relaxation, and leads to difficulties in predicting DNA's chemical and photophysical behavior.
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Fundamental Molecular Mechanisms of DNA Damage
  • 批准号:
    RGPIN-2015-06247
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $2.04万
  • 财政年份:
    2019
  • 负责人:
    Loppnow, Glen
  • 依托单位:
Fundamental Molecular Mechanisms of DNA Damage
  • 批准号:
    RGPIN-2015-06247
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $2.04万
  • 财政年份:
    2018
  • 负责人:
    Loppnow, Glen
  • 依托单位:
Fundamental Molecular Mechanisms of DNA Damage
  • 批准号:
    RGPIN-2015-06247
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $2.04万
  • 财政年份:
    2017
  • 负责人:
    Loppnow, Glen
  • 依托单位:
Fundamental Molecular Mechanisms of DNA Damage
  • 批准号:
    RGPIN-2015-06247
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $2.04万
  • 财政年份:
    2016
  • 负责人:
    Loppnow, Glen
  • 依托单位:
国内基金
海外基金
Kidney injury molecular(KIM-1)介导肾小管上皮细胞自噬在糖尿病肾病肾间质纤维化中的作用
  • 批准号:
    81300605
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    23.0万元
  • 批准年份:
    2013
  • 负责人:
    唐琳
  • 依托单位:
Molecular Plant
Molecular Interaction Reconstruction of Rheumatoid Arthritis Therapies Using Clinical Data
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