Characterization and role of the Drug / Metabolite Transporter (DMT) superfamily in drug resistance using a bodonid kinetoplastid model

对寄生虫病的研究创造了许多机会和挑战，因为所有人和牲畜的寄生虫感染都是通过药物的使用来控制的。这些药物已经连续使用了60多年，因此产生了抗药性或耐受性。由于疫苗不是(目前)许多此类感染的可行选择，药物是控制计划的中流砥柱。对于大多数寄生虫病来说，迫切需要开发新的更好的药物，但要做到这一点，就需要更好地了解耐药性，试图绕过或克服它，而且有必要寻找寄生虫的新的特定细胞靶点。该研究计划的长期目标是了解寄生虫耐药的机制(S)。为了实现这一目标，在未来五年内

Study of parasitic diseases creates a number of opportunities and challenges as all parasitic infections in humans and livestock are controlled by the use of drugs. These drugs have been in continuous use, in some cases for over 60 years, and as such a resistance or tolerance has developed. Since vaccines are not a viable option (at present) for many of these infections, drugs are the mainstay of control programs. For most parasitic diseases, there is an urgent need to develop new and better drugs but to do this an improved understanding of drug resistance, to try to circumvent or overcome it, and the search for new specific cellular targets of parasites are warranted. The long term objective of the research program is to understand the mechanism(s) of drug resistance in parasitic organisms. Towards realizing that goal, over the next five years the