Interfacing Mass Spectrometry with New Materials Developed for Fast Targeted Analysis

广泛而多样的环境污染源导致公众担心清洁水、空气和食物的可获得性受到威胁。这种压力增加了对广泛和频繁检测的需求，以确保健康、安全和资源质量。在这种背景下，我正在进行的研究计划是开发对水样进行高通量筛选所必需的灵敏、快速、简单的分析方法，这些方法也适用于废水评估和处理计划。这里提出的工作有两个相互关联的研究主题：A)开发选择性材料，主要是分子印迹聚合物(MIP)膜，用于从水溶液中吸收目标分析物；B)开发解吸电喷雾电离-质谱仪(DESI-MS)方法，用于直接询问选择性吸附剂中的分析物。

Widespread and varied sources of environmental contamination has led to public concern about threats to the availability of clean water, air and food. Such pressures increase demands to test broadly and frequently to assure health, safety and resource quality. This context motivates my ongoing research program to develop sensitive, fast, simple analytical approaches necessary for high throughput screening of aqueous samples, which are also suitable for use in wastewater assessment and treatment programs. The work proposed here has two interrelated research themes: A) development of selective materials, principally molecularly imprinted polymer (MIP) films, for uptake of target analytes from aqueous solutions, and B) development of desorption electrospray ionization-mass spectrometry (DESI-MS) methods for direct interrogation of analytes in the selective sorbents.