Biochemical, proteomic and microscopic insights into regulation of nucleolar structure and function
Biochemical, proteomic and microscopic insights into regulation of nucleolar structure and function
批准号:
RGPIN-2015-06674
负责人:
TrinkleMulcahy, Laura
金额:
$2.48万
依托单位:
依托单位国家:
加拿大
项目类别:
Discovery Grants Program - Individual
财政年份:
2015
资助国家:
加拿大
项目状态:
已结题
起止时间:
2015-01-01 至 2016-12-31
中文摘要
哺乳动物核仁是一种非膜结合的核细胞器,它围绕核糖体DNA的串联重复序列形成,并且最为人所知的是其在核糖体生物合成的协调中的重要作用,其为细胞提供蛋白质合成所需的核糖体复合物。这种结构是动态的,在哺乳动物细胞的每个细胞周期中分解和重组,并重组其内部结构以应对各种细胞应激。
英文摘要
The mammalian nucleolus is a non membrane-bound nuclear organelle that forms around tandem repeats of ribosomal DNA and is best known for its essential role in the coordination of ribosome biogenesis, which supplies the cell with the ribosome complexes required for protein synthesis. This structure is dynamic, disassembling and reassembling throughout each cell cycle in mammalian cells and reorganizing its internal structure in response to various cellular stresses.
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Temporal resolution of phosphorylation-mediated signalling events in DNA Damage Repair
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.62万
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Temporal resolution of phosphorylation-mediated signalling events in DNA Damage Repair
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批准号:RGPIN-2020-06612
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.62万
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财政年份:2020
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负责人:TrinkleMulcahy, Laura
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依托单位:
Biochemical, proteomic and microscopic insights into regulation of nucleolar structure and function
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批准号:RGPIN-2015-06674
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.48万
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负责人:TrinkleMulcahy, Laura
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依托单位:
Biochemical, proteomic and microscopic insights into regulation of nucleolar structure and function
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.48万
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Biochemical, proteomic and microscopic insights into regulation of nucleolar structure and function
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项目类别:Discovery Grants Program - Individual
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.33万
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负责人:TrinkleMulcahy, Laura
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依托单位:
海外基金