Optical Tweezers for probing intermolecular and interparticle interactions in complex fluids with extreme sensitivity

所要求的光钳系统是最新型号和世界上性能最高的系统之一，专为操纵单个纳米和微观物体而设计，例如纳米和微粒子、活细胞、乳液滴和生物大分子(例如蛋白质和核酸)，同时以亚纳米精度测量被困物体的三维位移，并以飞牛顿(10^(-15)N)分辨率量化相互作用力，适用于广泛的材料(例如聚合物、生物聚合物、蛋白质、纳米颗粒、细胞)、生物和工程系统(例如油砂工程、矿物加工)在复杂流体中。建议的光学镊子系统是由计算机控制的，并包括一个用户友好的图形界面。一个关键的特点是，光学捕获系统与等离子体增强相结合，便于捕获直径小于10 nm的纳米粒子和单个大分子，这是其他光镊子系统所不能实现的。该系统还使用集成噪声捕食器的陷波光束的主动强度稳定，提供最低的噪声水平和最高的稳定性，以准确检测市场上可用的最小作用力。力和位移检测系统的校准序列对于精确的力测量至关重要，可以在不需要特殊样品的情况下在现场自动进行。

The requested optical tweezers system is the latest model and one of the world’s highest performance systems designed for manipulation of single nanoscopic and microscopic objects, such as nano- and microparticles, live cells, emulsion droplets and biomacromolecules (e.g. proteins and nuclei acids), while simultaneously measuring the three-dimensional displacement of the trapped object with sub-nanometer accuracy as well as quantifying the interaction force with femtonewton (10^(-15) N) resolution, for a broad range of materials (e.g., polymers, biopolymers, proteins, nanoparticles, cells), biological and engineering systems (e.g. oil sands engineering, mineral processing) in complex fluids. The proposed optical tweezers system is computer-controlled and includes a user-friendly graphical interface. One key feature is that the optical trapping system is coupled with plasmonic enhancement facilitating trapping of nanoparticles and single macromolecules with diameters down to 10 nm, which is not achievable with other optical tweezer systems. The system also uses active intensity stabilization of trapping beams with integrated noise eaters, providing the lowest noise levels and the highest stability for accurately detecting the smallest force, available on the market. The calibration sequence of the force and displacement detection system, which is vital for precise force measurement, can be automatically conducted in situ without the need for special samples.