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Telomere instability transforms differentiated stem cells into teratomas: implications for aging and disease

Telomere instability transforms differentiated stem cells into teratomas: implications for aging and disease
端粒不稳定性将分化干细胞转化为畸胎瘤:对衰老和疾病的影响
批准号:
347300
负责人:
Harrington Lea A
金额:
$48.73万
依托单位:
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2016
资助国家:
加拿大
项目状态:
已结题
起止时间:
2016-03-01 至 2020-03-01

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中文摘要
翻译
干细胞是产生我们身体所有组织的祖细胞群,负责将我们的基因组稳定繁殖到下一代。为了响应外部和内部的线索,干细胞致力于特定的细胞
英文摘要
Stem cells are the progenitor cell populations that give rise to all tissues in our body, and are responsible for the stable propagation of our genomes into the next generation. In response to external and internal cues, stem cells commit to specific cell
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Exploiting the synthetic-lethal vulnerabilities of stem cells and cancer cells with eroded telomeres
  • 批准号:
    445608
  • 项目类别:
    Operating Grants
  • 资助金额:
    $64.09万
  • 财政年份:
    2021
  • 负责人:
    Harrington Lea A
  • 依托单位:
Genetic and chemical ablation of senescent cells that result from age-dependent telomere erosion
  • 批准号:
    398885
  • 项目类别:
    Operating Grants
  • 资助金额:
    $32.68万
  • 财政年份:
    2018
  • 负责人:
    Harrington Lea A
  • 依托单位:
Telomere integrity and stability of the differentiated state
  • 批准号:
    293207
  • 项目类别:
    Operating Grants
  • 资助金额:
    $58.13万
  • 财政年份:
    2013
  • 负责人:
    Harrington Lea A
  • 依托单位:
海外基金