Roles of the tumor suppressor PALB2 at the crossroads of DNA double-strand break repair and synthetic lethal strategies
Roles of the tumor suppressor PALB2 at the crossroads of DNA double-strand break repair and synthetic lethal strategies
批准号:
355281
负责人:
Masson Jean-Yves
金额:
$70.5万
依托单位:
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2016
资助国家:
加拿大
项目状态:
已结题
起止时间:
2016-10-01 至 2021-10-01
中文摘要
癌症是我国死亡的主要原因。癌症形成的初始事件涉及遗传物质的突变。近年来,越来越清楚的是,关键DNA修复酶(如PALB2和BRCA2)的突变起了作用
英文摘要
Cancer is the leading cause of death in our country. The initial event for cancer formation involves mutations in the genetic material. In recent years, it has been increasing clear that mutations in key DNA repair enzymes such as PALB2 and BRCA2 contribu
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Canada Research Chairs - Tier 1
-
批准号:424788
-
项目类别:
-
资助金额:$101.99万
-
财政年份:2019
-
负责人:Masson Jean-Yves
-
依托单位:
Patient stratification based on DNA repair functionality for cancer precision medicine
-
批准号:406820
-
项目类别:Operating Grants
-
资助金额:$23.52万
-
财政年份:2019
-
负责人:Masson Jean-Yves
-
依托单位:
Decoding the DNA double-strand break repair pathways: from mechanistic insights to human genome instability diseases
-
批准号:369216
-
项目类别:Operating Grants
-
资助金额:$245.17万
-
财政年份:2017
-
负责人:Masson Jean-Yves
-
依托单位:
Mechanisms and regulation of DNA end resection in mammalian cells
-
批准号:343190
-
项目类别:Operating Grants
-
资助金额:$59.59万
-
财政年份:2016
-
负责人:Masson Jean-Yves
-
依托单位:
Interplay between homologous recombination and anti-recombination activities at broken DNA replication forks and genomic instability
-
批准号:277932
-
项目类别:Operating Grants
-
资助金额:$37.47万
-
财政年份:2013
-
负责人:Masson Jean-Yves
-
依托单位:
2nd Canadian Symposium on Telomeres and Genome Integrity
-
批准号:298901
-
项目类别:Miscellaneous Programs
-
资助金额:$1.82万
-
财政年份:2013
-
负责人:Masson Jean-Yves
-
依托单位:
Functions of the tumor suppressor PALB2 in DNA double-strand break repair and tumorigenesis
-
批准号:210642
-
项目类别:Operating Grants
-
资助金额:$54.08万
-
财政年份:2010
-
负责人:Masson Jean-Yves
-
依托单位:
MRE11-RAD50-NBS1: at the crossroads of DNA double-strand break repair and Fanconi anemia
-
批准号:188788
-
项目类别:Operating Grants
-
资助金额:$59.85万
-
财政年份:2009
-
负责人:Masson Jean-Yves
-
依托单位:
海外基金