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Control of inflammation by a novel cytosolic Unfolded Protein Response (UPR) pathway

Control of inflammation by a novel cytosolic Unfolded Protein Response (UPR) pathway
通过新型胞质未折叠蛋白反应 (UPR) 途径控制炎症
批准号:
357366
负责人:
Girardin Stephen E
金额:
$65.76万
依托单位:
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2016
资助国家:
加拿大
项目状态:
已结题
起止时间:
2016-10-01 至 2021-10-01

项目摘要

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中文摘要
翻译
炎症是由几个蛋白质家族控制的,当它们被激活时,它们聚集在一起形成大簇。因为这种组装非常像一个“链式反应”,它需要在分子水平上进行控制,否则这些簇就会破裂
英文摘要
Inflammation is controlled by several families of proteins that assemble in large clusters when they are activated. Because this assembly is very much like a "chain reaction" it needs to be controlled at a molecular level, otherwise these clusters would p
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会议论文
Induction of intestinal revSCs by a bacterial metabolite
  • 批准号:
    488049
  • 项目类别:
    Operating Grants
  • 资助金额:
    $74.96万
  • 财政年份:
    2023
  • 负责人:
    Girardin Stephen E
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Mitochondrial protein import stress (MPIS) pathways
  • 批准号:
    477303
  • 项目类别:
    Operating Grants
  • 资助金额:
    $7.29万
  • 财政年份:
    2022
  • 负责人:
    Girardin Stephen E
  • 依托单位:
The impact of early-life enteric infection on the development of Crohn's disease
  • 批准号:
    420463
  • 项目类别:
    Operating Grants
  • 资助金额:
    $58.24万
  • 财政年份:
    2020
  • 负责人:
    Girardin Stephen E
  • 依托单位:
Canada Research Chairs - Tier 1
  • 批准号:
    441793
  • 项目类别:
  • 资助金额:
    $101.99万
  • 财政年份:
    2020
  • 负责人:
    Girardin Stephen E
  • 依托单位:
海外基金