Validation of the Nlrp1-Casp1-Casp6 pathway as an early therapeutic target of age-dependent cognitive impairment and Alzheimer Disease.
Validation of the Nlrp1-Casp1-Casp6 pathway as an early therapeutic target of age-dependent cognitive impairment and Alzheimer Disease.
批准号:
356925
负责人:
Leblanc Andra C
金额:
$67.43万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2016
资助国家:
加拿大
项目状态:
已结题
起止时间:
2016-10-01 至 2021-10-01
中文摘要
我们研究的目标是确定老年人类大脑中的早期退行性事件,这些事件可以被预防或治疗,以阻止年龄依赖性记忆丧失和随后发生在阿尔茨海默病中的痴呆。我们关注的是一种酶蛋白na
英文摘要
The goal of our research is to identify early degenerative events in aged human brains that can be prevented or treated to stop age-dependent memory loss and the ensuing dementia that occurs in Alzheimer Disease. We have focused on an enzymatic protein na
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会议论文
Role of caspases in human neuronal cell death and in Alzheimer's disease.
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批准号:223286
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项目类别:Operating Grants
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资助金额:$56.92万
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财政年份:2011
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负责人:Leblanc Andra C
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依托单位:
Detection of Tau cleaved by Caspase-6 in the cerebrospinal fluid of individuals with age-related cognitive impairment and Alzheimer disease.
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批准号:188341
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项目类别:Operating Grants
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资助金额:$3.58万
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财政年份:2009
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负责人:Leblanc Andra C
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依托单位:
Regulation of Prion Protein Expression, Trafficking and Function.
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批准号:188340
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项目类别:Operating Grants
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资助金额:$50.24万
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财政年份:2009
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负责人:Leblanc Andra C
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依托单位:
海外基金