The molecular basis of meiotic crossover distribution

我的实验室已经确定了一个基因的分子基础，该基因负责建立秀丽隐杆线虫减数分裂中交叉事件的分布。 这是一个重要的结果，因为表型orec-1是独特的，因为它改变了测量的交换事件的位置，而对重组频率、繁殖力或发育过程没有任何其他可测量的影响。 rec-1基因的一个显著特征是它在一级序列水平上与其他物种保守性差，尽管迄今为止表征的所有物种都显示出减数分裂模式，这是另一种说法，即交换的分布沿染色体沿着不均匀。 对于这一明显的悖论有许多解释;然而，这里将要检验的假设是，rec-1是一个例子，

My laboratory has identified the molecular basis of a gene responsible for establishing the distribution of crossover events in meiosis of Caenorhabditis elegans.  This is a significant result because the phenotype o rec-1 is unique in that it alters the position of the measured crossover event without any other measurable effects on frequency of recombination, fecundity or developmental processes.  A notable feature of the rec-1 gene is that it is poorly conserved at the level of primary sequence with other species, even though all species characterized to date show a meiotic pattern, which is another way of saying that the distribution of crossing over is not uniform along a chromosome.  There are a number of explanations for this apparent paradox; however the hypothesis that will be tested here is that rec-1 is an example of a