Bacterial effector proteins as tools to study cell biology

一些细菌将蛋白质注入人体细胞以改变人体细胞的功能。通过研究这些细菌蛋白质是如何工作的，我们可以了解到关于人类细胞功能的新知识。我们小组和其他人过去对细菌如何改变人类细胞在细胞中移动的途径的研究，揭示了人类细胞如何调节其形状和结构的新见解。在目前的提案中，我们将扩展我们对一组新的细菌蛋白的研究，这些细菌蛋白可以改变人类细胞蛋白在细胞内不同部位的传递。我们预计这些研究将导致对这些过程的新见解。

Some bacteria inject proteins into human cells to alter human cell function. By studying how these bacterial proteins work, we can learn new things about how human cells function. Past studies by our group and others of how bacteria alter human cell pathways to move around in cells has revealed new insights into how human cells regulate their shape and structure. In the current proposal, we will extend our studies on a new set of bacterial proteins that alter the delivery of human cell proteins to different sites within the cell. We anticipate that these studies will lead to new insights into these processes.