A New Cellular Protein Degradation Pathway for Lysosome Homeostasis and Remodeling

尽管他们可能没有意识到，每个人都在循环利用以维持地球上的生命——至少从细胞生物学家的角度来看是这样。这是因为所有的真核细胞，包括那些构成你和我的细胞，都依赖于一种叫做溶酶体的细胞器来回收生物材料。溶酶体回收不需要的或受损的细胞成分，并通过将细胞外碎片或病原体转化为重要的营养来源来清除它们。因此，当细胞饥饿时，需要溶酶体的活性来维持新陈代谢，并清除细胞老化时积累的有毒生物物质。为了发挥作用，这些动态细胞器依靠营养转运体将分解代谢产物（氨基酸、脂质、核酸）返回细胞以供再利用。但人们对这些转运蛋白知之甚少，包括它们是如何被调节或降解的。直到最近，当我们在模式生物中发现了一个新的过程

Although they may not be aware, everyone recycles to sustain life on earth – at least from the perspective of a cell biologist. This is because all eukaryotic cells, including those that constitute you and I, rely on organelles called lysosomes to recycle biomaterials. Lysosomes recycle unneeded or damaged cellular components, and clear extracellular debris or pathogens by converting them into an important source of nutrients. As such, lysosome activity is needed to sustain metabolism when cells are starved, and to remove toxic biomaterials that accumulate in cells as they age. To function, these dynamic organelles rely on nutrient transporters to return products of catabolism (amino acids, lipids, nucleic acids) to the cell for reuse. But little is know about these transporters including how they are regulated or degraded. Until recently, when we discovered a new process in the model organism