To roles of EPH kinases in regulating catecholamine secretion in chromaffin cells

申请人是促红细胞生成素肝细胞激酶（EPH）研究的先驱。这些研究代表了自2000年以来的一项重大长期计划（由NSERC和其他来源提供资金）。这个长期项目的目标是在细胞和分子水平上阐明不同的EPH及其配体ephrin（EFN）如何调节血压（BP）和免疫系统的潜在机制。三到六个博士学生将在未来10年内接受该方案的培训。

The applicant is a pioneer in research on erythropoietin-producing hepatocyte kinases (EPHs). These studies represent a major, long-term program since 2000 (with funding from NSERC and other sources). The objectives of this long-term program focus on elucidating underlying mechanisms at the cellular and molecular levels with regard to how different EPHs and their ligand ephrins (EFNs) modulate blood pressure (BP) and the immune system. Three to 6 Ph.D. students will be trained in the next 10 years in this program.