Regulation of clathrin adaptor complexes

笼状蛋白适配器蛋白(AP)复合体通过识别特定细胞器上的货物，并招募外壳成分来形成运输囊泡来调节蛋白质的运输。我们的长期目标是确定调节AP复合体不同功能的机制。在这项提案中，我们将表征调节APü1复合体在介导高尔基体/内体转运中的活性的新蛋白质，重点是促进被膜组装和膜曲率的脂质修饰酶。

Clathrin adaptor protein (AP) complexes regulate protein trafficking by recognizing cargo at specific organelles, and recruiting coat components to make a transport vesicle. Our long term objective is to identify mechanisms that regulate the differential functions of AP complexes. In this proposal, we will characterize novel proteins that regulate the activity of the AP­1 complex in mediating Golgi/endosomal transport, with a focus on lipid-modifying enzymes that promote coat assembly and membrane curvature.