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Nucleotide excision repair of UV induced DNA damage and chromatin structure in the model organism S. cerevisiae

Nucleotide excision repair of UV induced DNA damage and chromatin structure in the model organism S. cerevisiae
模式生物酿酒酵母中紫外线诱导的 DNA 损伤和染色质结构的核苷酸切除修复
批准号:
RGPIN-2017-05495
负责人:
Conconi, Antonio
金额:
$2.04万
依托单位:
依托单位国家:
加拿大
项目类别:
Discovery Grants Program - Individual
财政年份:
2017
资助国家:
加拿大
项目状态:
已结题
起止时间:
2017-01-01 至 2018-12-31

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中文摘要
翻译
细胞积累DNA损伤,必须修复以维持基因组稳定性。 核苷酸切除修复(NER)去除紫外线诱导的DNA损伤,当存在于基因转录链上时,阻断RNA聚合酶。 NER在生物体中是保守的;我们使用酵母作为遗传学上易于处理的模型来研究NER如何运作
英文摘要
Cells accumulate DNA damage that must be repaired to maintain genome stability. Nucleotide Excision Repair (NER) removes UV induced DNA damage that, when present on gene transcribed strands, block RNA polymerases. NER is conserved across organisms; we use yeast as genetically tractable model to study how NER operates
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Nucleotide excision repair of UV induced DNA damage and chromatin structure in the model organism S. cerevisiae
  • 批准号:
    RGPIN-2017-05495
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $2.04万
  • 财政年份:
    2022
  • 负责人:
    Conconi, Antonio
  • 依托单位:
Nucleotide excision repair of UV induced DNA damage and chromatin structure in the model organism S. cerevisiae
  • 批准号:
    RGPIN-2017-05495
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $2.04万
  • 财政年份:
    2021
  • 负责人:
    Conconi, Antonio
  • 依托单位:
Nucleotide excision repair of UV induced DNA damage and chromatin structure in the model organism S. cerevisiae
  • 批准号:
    RGPIN-2017-05495
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $2.04万
  • 财政年份:
    2020
  • 负责人:
    Conconi, Antonio
  • 依托单位:
Nucleotide excision repair of UV induced DNA damage and chromatin structure in the model organism S. cerevisiae
  • 批准号:
    RGPIN-2017-05495
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $2.04万
  • 财政年份:
    2019
  • 负责人:
    Conconi, Antonio
  • 依托单位:
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